Fig. 2

METTL14 promoted high glucose-induced glomerular endothelial cell injury. A Expression of METTL14 was examined by qRT-PCR after transfected with Vector or MELLT14 plasmid. **P < 0.01 vs. Vector. B Expression of METTL14 was examined by qRT-PCR after transfected with si-ctrl or MELLT14 siRNA. **P < 0.01 vs. si-Ctrl. C–E The levels of ROS, TNF-α and IL-6 were detected by ELISA. F Cell proliferation was assessed by CCK-8. G, H Cell apoptosis was analysed by TUNEL staining, Scale bar: 50 µm. *P < 0.05, **P < 0.01 vs. NG; ^#P < 0.05, ^##P < 0.01 vs. HG + Vector; ^&P < 0.05, ^&&P < 0.01 vs. HG + si-Ctrl. Data are presented as the mean ± SD (n = 3)