Fig. 5

METTL14 promoted renal injury in db/db mice and rescued by α-klotho. A–D 24-h urine protein level, BW, KW and KHI was assessed. E H&E immunostaining was performed to detect general morphological changes. Scale bar = 25 µm. F Masson staining was assessed to examination of matrix deposition. Scale bar = 25 µm. BW body weight, KW kidney weight; KHI = KW/BW. Data are presented as the mean ± SD (n = 6); *P < 0.05, **P < 0.01 vs. db/m; ^#P < 0.05, ^##P < 0.01 vs. db/db + rAAV; ^&P < 0.05, ^&&P < 0.01 vs. db/db + rAAV-METTL14.