MiR-146b-5p-mediated sh-MINCR protected against lipopolysaccharide (LPS)-induced acute lung injury (ALI). A total and neutrophil counts in bronchoalveolar lavage fluid (BALF) mice. B mouse BALF myeloperoxidase (MPO) activity. C hematoxylin and eosin staining. Scale bar = 50 μm. D terminal deoxynucleotidyl transferase biotin-dUTP nick end labeling staining was used to detect apoptosis. Scale bar = 50 μm. E F4/80 IHC staining. Scale bar = 50 μm. F quantification of levels of TNF (tumor necrosis factor)-α, IL (interleukin)-6, and IL-10 were examined by enzyme-linked immunosorbent assay. *p < 0.05, **p < 0.01, ***p < 0.001 vs. Ctrl group; #p < 0.05 vs. LPS. N = 10.