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Fig. 2 | Molecular Medicine

Fig. 2

From: Increased hemoglobin and heme in MALDI-TOF MS analysis induce ferroptosis and promote degeneration of herniated human nucleus pulposus

Fig. 2

Specific increase in heme content in herniated nucleus pulposus as analyzed by MALDI-TOF MS. a MS spectra of Hb standard at a low-mass range. b The spectra of tissue lysates from herniated nucleus pulposus and nonherniated nucleus pulposus in the low-mass range. The tissue samples were obtained from the patients 14 and 4 in Table 1. c–d The total intensity (c) and average intensity (d) of heme and its isotope peaks in 10 samples of herniated nucleus pulposus and 6 samples of nonherniated nucleus pulposus. The data were analyzed with GraphPad Prism 5.02 software. **P < 0.01. e ROC curve analysis of the heme peaks of 10 samples of herniated nucleus pulposus and 6 samples of nonherniated nucleus pulposus

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