Skip to main content
Fig. 4 | Molecular Medicine

Fig. 4

From: Suppression of CRLF1 promotes the chondrogenic differentiation of bone marrow-derived mesenchymal stem and protects cartilage tissue from damage in osteoarthritis via activation of miR-320

Fig. 4

CRLF1 3′-UTR is the direct target of miR-320 in BMSCs. A Target sequence in the 3'-UTR of CRLF1 predicted to bind miRNA-320 and miR-125a-3p. B Luciferase activity of BMSCs co-transfected with WT or Mut CRLF1 3’-UTR and miRNA-320/miR-125a-3p mimic or inhibitor. C RT-qPCR and D WB measured the effect of miRNA-320 mimic or inhibitor on CRLF1 expression. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001

Back to article page