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Fig. 5 | Molecular Medicine

Fig. 5

From: Suppression of CRLF1 promotes the chondrogenic differentiation of bone marrow-derived mesenchymal stem and protects cartilage tissue from damage in osteoarthritis via activation of miR-320

Fig. 5

miR-320 could reverse the effect of CRLF1 on cell proliferation, apoptosis and chondrogenic differentiation of BMSCs. A Cell viability was estimated in BMSCs co-transfected with pEGFP-CRLF1and miR-320 mimic. B Apoptosis was examined by flow cytometric analysis using Annexin V/PI assay. C The deposition of cartilage matrix proteoglycans was determined by Alcian blue staining (scale bar, 50 Î¼m). D Protein expressions of ACAN, Sox9, Col2a1, collagen X and MMP13 were analyzed by western blot. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001

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Molecular Medicine

ISSN: 1528-3658