Table 2 Associations between gene methylation and the CRC risk in GEO dataset
Gene | Hypomethylation | Hypermethylation | OR (95%CI) | *P value | ORadj (95%CI) | *P value |
|---|---|---|---|---|---|---|
PDCD-1 (cg06291111) | ||||||
 CRCs (n = 166), n% | 142 (85.54%) | 24 (14.46%) |  |  < 0.0001 |  |  < 0.0001 |
 Controls (n = 424), n% | 267 (62.97%) | 157 (37.03%) | 0.287 (0.179–0.462) |  | 0.322 (0.197–0.528) |  |
LAG-3 (cg10191002) | ||||||
 CRCs (n = 166), n% | 66 (39.76%) | 100 (60.24%) |  | 0.004 |  | 0.048 |
 Controls (n = 424), n% | 116 (27.36%) | 308 (72.64%) | 0.571 (0.391–0.832) |  | 0.666 (0.446–0.996) |  |