Table 4 Association between methylation levels of PDCD-1, LAG-3 in PBL and CRC risk
Gene | Hypomethylation | Hypermethylation | OR (95%CI) | *P value | ORadj (95%CI) | *P value |
|---|---|---|---|---|---|---|
PDCD-1 | ||||||
 CRCs (n = 389), n% | 159 (40.87%) | 230 (59.13%) |  | < 0.0001 |  | < 0.0001 |
 Controls (n = 386), n% | 92 (23.83%) | 294 (76.17%) | 0.453 (0.332–0.617) |  | 0.448 (0.322–0.622) |  |
LAG-3 | ||||||
 CRCs (n = 390), n% | 169 (43.33%) | 221 (56.67%) |  | < 0.0001 |  | < 0.0001 |
 Controls (n = 397), n% | 108 (27.20%) | 289 (72.80%) | 0.489 (0.363–0.659) |  | 0.417 (0.301–0.578) |  |