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Table 5 Associations between the methylation of individual genes and CRC risk stratified by age

From: Inhibitory immune checkpoints PDCD-1 and LAG-3 hypermethylation may reduce the risk of colorectal cancer

Subgroup

No. of hypermethylation (CRCs/controls)

No. of hypomethylation (CRCs/controls)

OR (95% CI)

P valuea

P valueb

PDCD-1

 Age, years

   < 60

102/166

78/56

0.441 (0.289–0.673)

< 0.0001

 

   ≥ 60

110/105

71/31

0.457 (0.278–0.754)

0.002

0.914

LAG-3

 Age, years

   < 60

105/179

75/43

0.336 (0.215–0.525)

< 0.0001

 

   ≥ 60

98/91

83/45

0.584 (0.368–0.926)

0.022

0.092

  1. CRC, colorectal cancer; CI, confidence interval; OR, odds ratio
  2. aP values were calculated using Logistic regression analysis, P values < 0.025 were considered statistically significant and  were indicated in bold
  3. bTest for heterogeity between ORs was conducted by fixed effect models with STATA (version 14), P values < 0.05 were considered statistically significant