Table 6 Effects of combination and interaction between methylation of PDCD-1 and LAG-3
Gene | PDCD-1 | Interaction | ||
|---|---|---|---|---|
Hypomethylation | Hypermethylation | |||
OReg (95% CI) | ORi (95% CI) | *P value | ||
LAG-3 | ||||
 Initial findings | ||||
  Hypomethylation |  | 0.579 (0.326–1.028) |  |  |
  Hypermethylation | 0.548 (0.307–0.978) | 0.217 (0.127–0.370) | 0.683 (0.341–1.371) | 0.283 |
 GEO dataset | ||||
  Hypomethylation |  | 0.264 (0.128–0.545) |  |  |
  Hypermethylation | 0.503 (0.324–0.782) | 0.135 (0.067–0.271) | 1.017 (0.383–2.676) | 0.980 |