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Fig. 3 | Molecular Medicine

Fig. 3

From: MicroRNA-214 promotes alveolarization in neonatal rat models of bronchopulmonary dysplasia via the PlGF-dependent STAT3 pathway

Fig. 3

miR-214 overexpression induces alveolarization in neonatal rats with BPD. BPD neonatal rats were injected with miR-214 NC and miR-214 agomir. A ELISA quantification of the proinflammatory factor IL-1β in rats. B ELISA quantification of the proinflammatory factor TNF-ɑ in rats. C ELISA quantification of the proinflammatory factor IL-6 in rats. D ELISA quantification of ICAM-1 and Flt-1 levels in rats. E Giemsa staining of the number of macrophages in rats. F H&E staining of pulmonary microvascular (× 400). G H&E staining showing the number of alveoli, and alveolar growth. Data are summarized as mean ± standard deviation. *p < 0.05 vs. neonatal rats exposed to air. #p < 0.05 vs. BPD neonatal rats treated with miR-214 NC. Data comparisons between multiple groups were performed using one-way ANOVA and Tukey's for post hoc test. n = 3 for rats in each group

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