Fig. 1

Telemetry system for analyzing short-term and long-term changes in blood pressure. A representative blood pressure wave tracing from a single telemeter-implanted mouse. BP is measured at 500 Hz. B representative 24 h tracing of MAP using the same telemeter system. From the blood pressure wave, MAP is calculated every 10 s. These 10 s bins are averaged over 30 min. Gray background indicates dark cycle when mice are active. C average normotensive MAP, D average normotensive HR, E average normotensive body temperature and F average normotensive activity. MAP, HR, temperature and activity are analyzed during 12 h of dark cycle and light cycle. Data are represented as individual mouse data points with mean ± SEM. n = 44, ****p < 0.0001, paired t-test