Fig. 5
From: Hsp90 up-regulates PD-L1 to promote HPV-positive cervical cancer via HER2/PI3K/AKT pathway
Hsp90 regulated HPV16+ cervical cancer cell proliferation and migration via PD-L1. In Caski and SiHa cells A Western blotting image and analysis of Hsp90, HER2, AKT, p-AKT, PD-L1 expression in control, sh-NC, sh-Hsp90#1, sh-Hsp90#1+vector, and sh-Hsp90+PD-L1 groups. B MTT assay evaluating cell proliferation. C Transwell assay evaluating cell migration. D Western blotting assay was used to detect the expression of PD-L1 in PD-L1-deficient Caski and SiHa cells. E Western blotting image and analysis of Hsp90, HER2, AKT, p-AKT, PD-L1 in PD-L1-deficient or PD-L1-deficient+Hsp90 Caski and SiHa cells. F MTT assay evaluating cell proliferation. G Transwell assay evaluating cell migration. N = 3 in each group. *p < 0.05, **p < 0.01 or ***p < 0.001