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Fig. 2 | Molecular Medicine

Fig. 2

From: Role of long non-coding RNA H19 in the development of osteoporosis

Fig. 2

Mechanism of H19 regulating osteogenic differentiation. (1) H19 Promotes osteoblast differentiation via the TGF-╬▓1/Smad3/HDAC signaling pathway by deriving miR-675. (2) H19 regulates the Notch signaling pathway by regulating downstream miRNA expression ligands to promote the osteogenic differentiation of MSCs induced by BMP9 (3) H19 is the miRNA sponge of miR141 and miR22, which antagonizes the negative regulatory effects of two miRNAs on the Wnt/╬▓catenin pathway. (4) H19 targets DKK4 to halt its inhibitory effect on the Wnt signaling pathway and osteogenic function. (5) miR-138 sponge reduces the expression of PTK2 gene by competitively binding with H19, promotes FAK expression, and induces osteogenic differentiation of MSCs. (6) H19 promotes the proliferation of osteoblasts by inhibiting the expression of p53. (7) The combination of H19 and Foxc2 synergistically promotes the osteogenic differentiation of bone marrow mesenchymal stem cells

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