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Fig. 3 | Molecular Medicine

Fig. 3

From: d-Serine produces antidepressant-like effects in mice through suppression of BDNF signaling pathway and regulation of synaptic adaptations in the nucleus accumbens

Fig. 3

d-Serine administration reverses the CSDS-induced increase in NAc BDNF signaling pathway. Moreover, K252a improves the effects of d-serine on the NAc BDNF signaling pathway. A Typical images of our western blotting results. B–D Our western blotting data displayed that d-serine administration reversed CSDS-induced increase of NAc BDNF, pTrkB, and pCREB protein levels. CSDS + d-serine mice showed meaningfully lower expression of BDNF, pTrkB, and pCREB in NAc than CSDS + vehicle mice. Furthermore, K252a improved d-serine-induced weakness of NAc BDNF, pTrkB, and pCREB expression, as CSDS + d-serine + K252a mice displayed significantly lower BDNF, pTrkB, and pCREB levels in NAc than CSDS + d-serine mice. Data are expressed as means ± SEM (n = 5);**P < 0.01, significantly different from control; ##P < 0.01, significantly different from CSDS + vehicle group. Comparisons were made by two-way ANOVA followed by post-hoc Bonferroni's test

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Molecular Medicine

ISSN: 1528-3658