Fig. 4From: d-Serine produces antidepressant-like effects in mice through suppression of BDNF signaling pathway and regulation of synaptic adaptations in the nucleus accumbensRetardant of BDNF signaling cascade by K252a infusion enhances the antidepressant effects of d-serine. The vehicle refers to 0.9% saline (injected into bilateral NAc). A Schematic timeline of experimental steps. After 14 days of CSDS, CSDS-susceptible mice received a daily injection of d-serine (2, 5 µg/perside) and K252a for another 14 days, after which behavioral tests were performed. B Pre-infusion of K252a significantly enhanced d-serine-induced reduction in immobility in FST. C Pre-infusion of K252a also enhanced d-serine-induced reduction in immobility in TST. D CSDS + d-serine + K252a mice showed significantly higher sucrose preference than CSDS + d-serine mice. E Co-treatment of d-serine with K252a also enhanced antidepressant effects of d-serine in the social interaction test. CSDS + d-serine + K252a mice showed significantly higher social interaction than CSDS + d-serine mice. The results are expressed as means ± SEM (n = 12), **P < 0.01 vs control; ##P < 0.01 vs CSDS + vehicle. Comparisons were made by two-way ANOVA followed by post hoc Bonferroni's testBack to article page