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Fig. 4 | Molecular Medicine

Fig. 4

From: d-Serine produces antidepressant-like effects in mice through suppression of BDNF signaling pathway and regulation of synaptic adaptations in the nucleus accumbens

Fig. 4

Retardant of BDNF signaling cascade by K252a infusion enhances the antidepressant effects of d-serine. The vehicle refers to 0.9% saline (injected into bilateral NAc). A Schematic timeline of experimental steps. After 14 days of CSDS, CSDS-susceptible mice received a daily injection of d-serine (2, 5 µg/perside) and K252a for another 14 days, after which behavioral tests were performed. B Pre-infusion of K252a significantly enhanced d-serine-induced reduction in immobility in FST. C Pre-infusion of K252a also enhanced d-serine-induced reduction in immobility in TST. D CSDS + d-serine + K252a mice showed significantly higher sucrose preference than CSDS + d-serine mice. E Co-treatment of d-serine with K252a also enhanced antidepressant effects of d-serine in the social interaction test. CSDS + d-serine + K252a mice showed significantly higher social interaction than CSDS + d-serine mice. The results are expressed as means ± SEM (n = 12), **P < 0.01 vs control; ##P < 0.01 vs CSDS + vehicle. Comparisons were made by two-way ANOVA followed by post hoc Bonferroni's test

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