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Fig. 6 | Molecular Medicine

Fig. 6

From: d-Serine produces antidepressant-like effects in mice through suppression of BDNF signaling pathway and regulation of synaptic adaptations in the nucleus accumbens

Fig. 6

d-Serine administration reversed the impaired NMDAR-dependent-LTD in NAc of CSDS mice. AC Averaged data demonstrated that LTD was induced in CSDS + fluoxetine mice, CSDS + d-serine (2 µg/perside) mice, and CSDS + d-serine (5 µg/perside) mice by LFS. D The column diagram demonstrated the level of LTD 40 min after LFS from control mice, CSDS mice, CSDS + fluoxetine mice, CSDS + d-serine (2 µg/perside) mice, and CSDS + d-serine (5 µg/perside) mice. Fluoxetine or d-serine administration reversed the damaged NMDA-LTD in NAc of CSDS mice. **P < 0.01 vs. control group; ##P < 0.01 vs. CSDS group. The superimposed fEPSP in the upper portion is recording from representative experiments taken at the time indicated by the number. Each point was normalized mean ± SEM of eight slices

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