Fig. 1

Dysfunctional expression of lncRNA SNHG1 and miR-181c-5p in OVX mice. Sixteen mice were randomly divided into sham group or ovariectomy (OVX) group. Eight weeks after the operation, mice were euthanized, femurs and serum were collected. A The SNHG1 and miR-181c-5p expressions in femoral tissue of were detected through qPCR. B The circulating levels of SNHG1 and miR-181c-5p in serum were measured through qPCR. C and D The protein levels of ALP, OCN, RUNX2, VEGF, NFATc1, RANKL and CTSK in femoral tissue were assessed by western blot assay. Per lane was loaded with protein collected from every four mice. **P < 0.01, ***P < 0.001 vs. sham mice