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Fig. 8 | Molecular Medicine

Fig. 8

From: lncRNA SNHG1 induced by SP1 regulates bone remodeling and angiogenesis via sponging miR-181c-5p and modulating SFRP1/Wnt signaling pathway

Fig. 8

LncRNA SNHG1 was activated by SP1. A The BMSCs were transfected with SP1 vector, sh-SP1 or their negative control, the levels of SP1 and lncRNA SNHG1 were measured using qPCR. B Predicted positions of putative SP1 binding motif in SNHG1 promoter using JASPAR. C Schematic presentation of SP1 binding sites in the promoter region of SNHG1. D ChIP-qPCR analysis showed the SP1 occupancy of SNHG1 promoter. E Dual luciferase reporter assay was conducted to verify SP1 binding sites on SNHG1 promoter region around F2. **P < 0.01, ***P < 0.001

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