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Fig. 4 | Molecular Medicine

Fig. 4

From: Human mesenchymal stem cells derived exosomes inhibit the growth of acute myeloid leukemia cells via regulating miR-23b-5p/TRIM14 pathway

Fig. 4

HMSC-exos induced the apoptosis of AML cells through delivering miR-23b-5p. A The mRNA level of miR-23b-5p of AML patients and healthy donators (n = 25 for each group). B The correlation between miR-23b-5p and TRIM14 in AML patients. C The expression of miR-23b-5p in HMSC-exos after co-cultured with miR-23b-5p mimic or inhibitor. D Flow cytometry detected the apoptosis of THP-1 cells after co-cultured with HMSC-exo-miNC, HMSC-exo-Mimic and HMSC-exo-inhibitor. E The expression of TRIM14, cleaved caspase-3, AKT and p-AKT in THP-1 cells after co-cultured with HMSC-exo-miNC, HMSC-exo-Mimic and HMSC-exo-inhibitor. *** p < 0.001; !!!*** p < 0.001 vs HMSC-exo-miNC

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