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Fig. 5 | Molecular Medicine

Fig. 5

From: Global identification of circular RNAs in imatinib (IM) resistance of chronic myeloid leukemia (CML) by modulating signaling pathways of circ_0080145/miR-203/ABL1 and circ 0051886/miR-637/ABL1

Fig. 5

Expression of circ_0080145, circ 0051886, miR-203, miR-637, ABL1 mRNA/protein and BCR/ABL1 were compared between the K562 group, K562/R + NC siRNA group, K562/R + circ_0080145 siRNA group, K562/R + circ_0051886 siRNA group and K562/R + circ_0080145 siRNA + circ_0051886 siRNA group (*P value < 0.05 vs. K562 group; **P value < 0.05 vs. K562/R + NC siRNA group). A The expression of circ_0080145 was increased in K562/R cells, which was subsequently suppressed by the presence of circ_0080145 siRNA; B The expression of circ_0051886 was increased in K562/R cells, which was subsequently suppressed by the presence of circ_0051886 siRNA; C The expression of miR-203 was decreased in K562/R cells, which was subsequently promoted by the presence of circ_0080145 siRNA; D The expression of miR-637 was increased in K562/R cells, which was subsequently promoted by the presence of circ_0080145 siRNA and/or circ_0051886 siRNA; E The expression of ABL1 mRNA was increased in K562/R cells, which was subsequently promoted by the presence of circ_0080145 siRNA and/or circ_0051886 siRNA; F The expression of ABL1 protein was increased in K562/R cells, which was subsequently promoted by the presence of circ_0080145 siRNA and/or circ_0051886 siRNA; G Cell proliferation of K562/R cells was generally higher than K562 cells, and the presence of circ_0080145 siRNA and/or circ_0051886 siRNA reduced the decreased cell proliferation rate in K562/R cells to a certain degree; H The apoptosis rate of K562/R cells was lower than K562 cells, and the presence of circ_0080145 siRNA and/or circ_0051886 siRNA reduced the increased the cell apoptosis rate in K562/R cells to a certain degree; I The expression of BCR/ABL1 mRNA in were generally higher in K562/R cells, and the presence of circ_0080145 siRNA and circ_0051886 siRNA exhibited no effect upon the expression of BCR/ABL1 mRNA

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