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Fig. 6 | Molecular Medicine

Fig. 6

From: Global identification of circular RNAs in imatinib (IM) resistance of chronic myeloid leukemia (CML) by modulating signaling pathways of circ_0080145/miR-203/ABL1 and circ 0051886/miR-637/ABL1

Fig. 6

Expression of circ_0080145, circ 0051886, miR-203, miR-637 and ABL1 mRNA/protein and BCR/ABL1 between the K562 group, K562 + p-circ_0080145 group, K562 + circ_0051886 group and K562 + p-circ_0080145 + p-circ_0051886 group (*P value < 0.05 vs. K562 group). A The expression of circ_0080145 was increased by the presence of p-circ_0080145 in K562 cells; B The expression of circ_0051886 was increased by the presence of p-circ_0051886 in K562 cells; C The expression of miR-203 was decreased by the presence of p-circ_0080145 in K562 cells; D The expression of miR-637 was decreased by the presence of p-circ_0051886 in K562 cells; E The expression of ABL1 mRNA was increased by the presence of p-circ_0080145 and/or p-circ_0051886 in K562 cells; F The expression of ABL1 protein was increased by the presence of p-circ_0080145 and/or p-circ_0051886 in K562 cells; G The proliferation of K562 cells was promoted by the presence of p-circ_0080145 and/or p-circ 0051886; H The apoptosis rate of K562 cells was suppressed by the presence of p-circ_0080145 and/or p-circ 0051886; I The expression of BCR/ABL1 mRNA was not influenced by the presence of p-circ_0080145 and/or p-circ_0051886 in K562 cells

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Molecular Medicine

ISSN: 1528-3658