Skip to main content
Fig. 4 | Molecular Medicine

Fig. 4

From: IκB kinase promotes Nrf2 ubiquitination and degradation by phosphorylating cylindromatosis, aggravating oxidative stress injury in obesity-related nephropathy

Fig. 4

IKK promoted oxidative stress injury caused by obesity through CYLD phosphorylation. The protein levels of p-CYLD, CYLD, and p-Nrf2. Nrf2, HO-1 and NQO1 were measured using western blotting in treated HK-2 cells. IKK, IκB kinase; CYLD, cylindromatosis; Nrf2, NF-E2-related factor 2; HO-1, haem oxygenase 1; NQO1, NAD(P)H dehydrogenase quinone 1; HK-2, human kidney 2. Significance was assessed by an ANOVA test. The experimental data are shown as the mean ± SD. N = 3. *P < 0.05, **P < 0.01, ***P < 0.001

Back to article page

Molecular Medicine

ISSN: 1528-3658