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Table 1 Validated DEGs in doxorubicin-induced cardiotoxicity

From: Weighted gene co-expression network-based approach to identify key genes associated with anthracycline-induced cardiotoxicity and construction of miRNA-transcription factor-gene regulatory network

Gene symbol Gene ID E-MTAB-1168 (12 mg/kg) GSE154603 (15 mg/kg) Change Gene symbol GSE157282 (1 μM) Change
4 week 6 week 5 week HiPSCM (24 h)
Casq1 686019 1.209 1.180 1.572 Up CASQ1
Fcgr2b 289211 1.436 1.052 1.356 Up FCGR2B
Postn 361945 1.446 1.735 1.422 Up POSTN
Tceal5 680282 2.452 1.611 1.449 Up TCEAL5
Ryr2 689560 − 1.382 − 1.355 − 1.463 Down RYR2 − 0.962 Down
Ccn2 64032 1.250 1.067 2.135 Up CCN2
Tnfrsf12a 302965 1.202 1.047 2.577 Up TNFRSF12A − 2.350 Down
Mybpc2 292879 1.460 1.648 1.475 Up MYBPC2
Ankrd23 316330 2.128 1.459 2.133 Up ANKRD23
Scn3b 245956 1.793 1.435 2.975 Up SCN3B 1.938 Up
  1. hiPSCM human induced pluripotent stem cell (hiPS)-derived cardiomyocyte