Weighted gene co-expression network-based approach to identify key genes associated with anthracycline-induced cardiotoxicity and construction of miRNA-transcription factor-gene regulatory network

Table 1 Validated DEGs in doxorubicin-induced cardiotoxicity

Gene symbol	Gene ID	E-MTAB-1168 (12 mg/kg)		GSE154603 (15 mg/kg)	Change	Gene symbol	GSE157282 (1 μM)	Change
Gene symbol	Gene ID	4 week	6 week	5 week	Change	Gene symbol	HiPSCM (24 h)	Change
Casq1	686019	1.209	1.180	1.572	Up	CASQ1	–	–
Fcgr2b	289211	1.436	1.052	1.356	Up	FCGR2B	–	–
Postn	361945	1.446	1.735	1.422	Up	POSTN	–	–
Tceal5	680282	2.452	1.611	1.449	Up	TCEAL5	–	–
Ryr2	689560	− 1.382	− 1.355	− 1.463	Down	RYR2	− 0.962	Down
Ccn2	64032	1.250	1.067	2.135	Up	CCN2	–	–
Tnfrsf12a	302965	1.202	1.047	2.577	Up	TNFRSF12A	− 2.350	Down
Mybpc2	292879	1.460	1.648	1.475	Up	MYBPC2	–	–
Ankrd23	316330	2.128	1.459	2.133	Up	ANKRD23	–	–
Scn3b	245956	1.793	1.435	2.975	Up	SCN3B	1.938	Up

ISSN: 1528-3658