Weighted gene co-expression network-based approach to identify key genes associated with anthracycline-induced cardiotoxicity and construction of miRNA-transcription factor-gene regulatory network

Table 2 Topological parameters of key nodes

Gene symbol	Attribution	Average shortest pathLength	Betweenness centrality	Closeness centrality	Degree
Ccn2	Core gene	2.12179487	0.50864445	0.47129909	64
Ankrd23	Core gene	2.31410256	0.38657305	0.43213296	55
Tnfrsf12a	Core gene	2.55769231	0.17317216	0.39097744	30
Scn3b	Core gene	2.62179487	0.1790707	0.38141809	29
Mybpc2	Core gene	2.73717949	0.10746715	0.36533958	23
Ryr2	Core gene	2.81410256	0.06456454	0.35535308	14
Tcf12	TF	2.28205128	0.05201617	0.43820225	5
Ctcf	TF	2.58974359	0.03352043	0.38613861	5
Spdef	TF	2.21794872	0.04987317	0.45086705	5
Ebf1	TF	2.82051282	0.018577	0.35454545	4
Sp1	TF	2.32051282	0.02773417	0.43093923	4
Rcor1	TF	2.33333333	0.02424099	0.42857143	4
miR-124-3p	miRNA	2.75641026	0.01849095	0.3627907	4
miR-195-5p	miRNA	2.42307692	0.01558517	0.41269841	3
miR-146a-5p	miRNA	2.67948718	0.01365674	0.37320574	3
miR-17-5p	miRNA	2.92307692	0.01346221	0.34210526	3
miR-15b-5p	miRNA	2.98717949	0.00362107	0.33476395	2
miR-424-5p	miRNA	2.98717949	0.00362107	0.33476395	2

ISSN: 1528-3658