Fig. 5

miR-200 family directly bind to lncRNA-ATB in HK-2 cells. a, b The expression levels of miR-200 family members a in HK-2 after COM stimulation and b in lncRNA-ATB knockdown cell lines. c The prediction for miR-200 family members’ binding sites on lncRNA-ATB transcript. d The binding sites of miR‐200a on lncRNA-ATB transcript are shown in green, and the mutant sequence is shown in red. e Dual‐luciferase reporter assays were performed using HK-2 cells cotransfected with miR-200a and luciferase reporters containing nothing, lncRNA-ATB wild-type (WT) or mutant transcript (MT). All above the experiments were repeated 3 times, values are mean ± SD; *P < 0.05, **P < 0.01 VS. Control, sh-NC or miR-NC group