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Fig. 1 | Molecular Medicine

Fig. 1

From: Fibroblast growth factor 21 attenuates salt-sensitive hypertension-induced nephropathy through anti-inflammation and anti-oxidation mechanism

Fig. 1

Treated with DOCA-salt for 8 days induced SSHN and increased expression of FGF21 in mice. Eight-week-old male FGF21 wild type (WT) mice based on C57BL/6J were treated with DOCA-salt or sham operation as controls. a The systolic blood pressure was monitored by a tail-cuff in DOCA-salt-induced hypertensive mice. b and c Urinary albumin levels and urinary albumin/creatinine ratio were elevated by treatment with DOCA-salt for 8 days. d and e Representative images of Hematoxylin–eosin-stained kidney sections showed obvious tubulointerstitial injury evidenced by aggravated epithelial cell necrosis and interstitial oedema in DOCA-salt-treated mice compared with that in the controls. f Serum FGF21 levels in the control and DOCA-salt-treated mice were determined by ELISA. g and h The changes of renal FGF21 expression in mice after treated with DOCA-salt for 8d using Western blot. GAPDH was used as loading and normalization control. i FGF21 mRNA expression in kidney tissues for the control and DOCA-salt-treated mice by Q-PCR analysis and values normalized to GAPDH. Quantitative data are presented as mean ± SD, n = 6 mice/group. *P < 0.05, **P < 0.01 versus the control group. Scale bar: 100 μm

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