Fig. 8From: Fibroblast growth factor 21 attenuates salt-sensitive hypertension-induced nephropathy through anti-inflammation and anti-oxidation mechanismMechanistic illustration of the basis of FGF21 protection against SSHN. FGF21 inhibits renal inflammation and oxidative stress by promoting AMPK phosphorylation via Nrf2-mediated antioxidant effects and inhibition of NF-κB-related inflammation, resulting in protection against DOCA-salt-induced SSHN in miceBack to article page