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Fig. 1 | Molecular Medicine

Fig. 1

From: PIAS3 suppresses damage in an Alzheimer’s disease cell model by inducing the STAT3-associated STAT3/Nestin/Nrf2/HO-1 pathway

Fig. 1

PIAS3 expression in CSF tissues of patients with AD and AD model. A qPCR analysis revealed PIAS3 expression in CSF tissues of patients with AD (n = 30) and normal participants (n = 10). BE SH-SY5Y cells were treated with Aβ (0, 5, 10, 20 μM in 0.1% DMSO) for 0, 12, 24, 36, 48, 60, and 72 h. qPCR and WB revealed the expression levels of PIAS3 in SH-SY5Y cells at the mRNA and protein levels. Data represent mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001. PIAS3 protein inhibitor of activated STAT3, CSF cerebrospinal fluid, qPCR quantitative polymerase chain reaction, AD Alzheimer’s disease, amyloid beta, DMSO dimethyl sulfoxide, WB western blotting

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