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Fig. 3 | Molecular Medicine

Fig. 3

From: Microfibrillar-associated protein 5 regulates osteogenic differentiation by modulating the Wnt/β-catenin and AMPK signaling pathways

Fig. 3

MFAP5 knockdown inhibited osteogenesis by affecting the Wnt/β-catenin and AMPK signaling pathways. A These pathways were activated in C3H10 and MC3T3-E1 cells during osteogenic induction; the levels of MFAP5, β-catenin, p-GSK-3β, AMPK, and p-AMPK increased, while that of GSK-3β decreased, as osteogenic induction proceeded. Wnt/β-catenin and AMPK signaling were inhibited in shRNA-transformed C3H10 and MC3T3-E1 cells throughout osteogenic differentiation. BD Relative protein levels of β-catenin, p-GSK-3β/ GSK-3β and p-AMPK/AMPK

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