Fig. 2

A Body weight of each mouse was recorded every 3 days (n = 5–6). B Fasting blood glucose (FBG) of each mouse was determined once a week (n = 5–6). C Fasting insulin (FINS) of each mouse was determined at the ending of study (n = 5–6). D HOMA-IR index was calculated according to standard formula: HOMA-IR = FBG (mmol) × FINS (mU/l)/22.5(n = 5–6). E For glucose tolerance test (GTT), all mice were fasted overnight and gavaged with glucose (2 g/kg), then the tail vein blood glucose was measured at 0, 30, 60, 90 and 120 min after gavage; the bar graph represents average area under the curve (n = 5–6). All data are presented as means ± SD. Compared to control group, *p < 0.05, **p < 0.01; Compared to model group, ^#p < 0.05, ^##p < 0.01, ^###p < 0.001