Fig. 3

A The forced swimming test (FST) were conducted after chronic restraint stress (CRS) treatment for 21 days, the immobility time of each mouse was recorded in the last 4 min (n = 5–6). B The open field test (OFT) were performed after chronic CRS treatment for 21 days, the total distance travelled of each mouse was recorded during the 5 min test (n = 5–6). C The tail suspension test (TST) were conducted after CRS treatment for 21 days, the immobility time of each mouse was recorded in the last 4 min (n = 5–6). D, E Serum depression-related neurotransmitters such as Noradrenaline (NE), serotonin (5-HT), and dopamine (DA) levels were detected at the end of the experiment (n = 5–6). G, H, I Serum tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and high-sensitivity C reactive protein (hs-CRP) levels were determined at the end of the experiment (n = 5–6). All data are presented as means ± SD. Compared to control group, *p < 0.05, **p < 0.01; Compared to model group, ^#p < 0.05, ^##p < 0.01