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Table 5 Functional characterization of XIST in nervous system tumors

From: Long non-coding RNA XIST: a novel oncogene in multiple cancers

Tumor types Expression Role Function role miRNAs Related genes References
Glioma Upregulation Oncogene Proliferation, migration, invasion, and apoptosis miR-152 / Yao et al. 2015)
Glioma Upregulation Oncogene Tumorigenicity and angiogenesis miR-429 / Cheng et al. 2017)
Glioma Upregulation Oncogene Angiogenesis miR-137 ZO-2/FOXC1 Yu et al. 2017)
Glioma Upregulation Oncogene Proliferation miR-137 Rac1 Wang et al. 2017c)
Glioma Upregulation Oncogene Viability, migration, invasion, apoptosis, and glucose metabolism miR-126 IRS1/PI3K/Akt Cheng et al. 2020)
Glioma Upregulation Oncogene Proliferation, metastasis, and emt miR-133a SOX4 Luo et al. 2020)
Glioma Upregulation Oncogene Proliferation, migration, invasion, and apoptosis miR-204-5p Bcl-2 Shen et al. 2020)
Glioma Upregulation Oncogene Stemness miR-152 KLF4 Gong et al. 2021)
Glioma Upregulation Oncogene Proliferation, invasion, apoptosis, and radio-sensitivity miR-329-3p CREB1 Wang et al. 2020c)
Neuroblastoma Upregulation Oncogene Cell cycle, proliferation, and radio-sensitivity miR-375 L1CAM Yang et al. 2020)