Long non-coding RNA XIST: a novel oncogene in multiple cancers

Table 5 Functional characterization of XIST in nervous system tumors

Tumor types	Expression	Role	Function role	miRNAs	Related genes	References
Glioma	Upregulation	Oncogene	Proliferation, migration, invasion, and apoptosis	miR-152	/	Yao et al. 2015)
Glioma	Upregulation	Oncogene	Tumorigenicity and angiogenesis	miR-429	/	Cheng et al. 2017)
Glioma	Upregulation	Oncogene	Angiogenesis	miR-137	ZO-2/FOXC1	Yu et al. 2017)
Glioma	Upregulation	Oncogene	Proliferation	miR-137	Rac1	Wang et al. 2017c)
Glioma	Upregulation	Oncogene	Viability, migration, invasion, apoptosis, and glucose metabolism	miR-126	IRS1/PI3K/Akt	Cheng et al. 2020)
Glioma	Upregulation	Oncogene	Proliferation, metastasis, and emt	miR-133a	SOX4	Luo et al. 2020)
Glioma	Upregulation	Oncogene	Proliferation, migration, invasion, and apoptosis	miR-204-5p	Bcl-2	Shen et al. 2020)
Glioma	Upregulation	Oncogene	Stemness	miR-152	KLF4	Gong et al. 2021)
Glioma	Upregulation	Oncogene	Proliferation, invasion, apoptosis, and radio-sensitivity	miR-329-3p	CREB1	Wang et al. 2020c)
Neuroblastoma	Upregulation	Oncogene	Cell cycle, proliferation, and radio-sensitivity	miR-375	L1CAM	Yang et al. 2020)

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