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Table 7 Functional characterization of XIST in other system tumors

From: Long non-coding RNA XIST: a novel oncogene in multiple cancers

Tumor types Expression Role Function role miRNAs Related genes References
Osteosarcoma Upregulation Oncogene Proliferation and invasion miR-137 / Li et al. 2019b)
Osteosarcoma Upregulation Oncogene Proliferation and invasion miR-320b RAP2B Lv et al. 2018)
Osteosarcoma Upregulation Oncogene Proliferation and invasion miR-193a-3p RSF1 Wu et al. 2017b)
Osteosarcoma Upregulation Oncogene Proliferation, autophagy, and apoptosis miR-375-3p AKT/mTOR Sun et al. 2019)
Osteosarcoma Upregulation Oncogene Migration, invasion, and emt miR-153 SNAIL Wen et al. 2020)
Osteosarcoma Upregulation Oncogene Proliferation and apoptosis miR-124-3p iASPP Hai et al. 2021)
Bladder cancer Upregulation Oncogene Clone formation and emt miR-200c / Xu et al. 2018a)
Bladder cancer Upregulation Oncogene Proliferation and migration miR-133a / Zhou et al. 2019)
Bladder cancer Upregulation Oncogene Proliferation, migration, and invasion miR-124 AR Xiong et al. 2017)
Bladder cancer Upregulation Oncogene Proliferation, migration, invasion, and apoptosis miR-139-5p Wnt/β-catenin Hu et al. 2017)
Bladder cancer Upregulation Oncogene Proliferation, migration, invasion, and emt miR-335 / Chen et al. 2020)
Retinoblastoma Upregulation Oncogene Proliferation, invasion, apoptosis, and emt miR-142-5p / Xu and Tian 2020)
Retinoblastoma Upregulation Oncogene Proliferation, cell cycle, and apoptosis miR-124 STAT3 Hu et al. 2018)
Retinoblastoma Upregulation Oncogene Proliferation, migration, invasion, apoptosis, and emt miR-101 ZEB1/ZEB2 Cheng et al. 2019)
Retinoblastoma Upregulation Oncogene Proliferation and invasion miR-140-5p SOX4 Wang et al. 2020d)
Retinoblastoma Upregulation Oncogene Proliferation, invasion, apoptosis, and emt miR-200a-3p NRP1 Zhao et al. 2020)
Retinoblastoma Upregulation Oncogene Proliferation, migration, invasion, autophagy, and apoptosis miR-361-3p STX17 Yang et al. 2020)
Retinoblastoma Upregulation Oncogene Proliferation, autophagy, and drug sensitivity miR-204-5p / Yao et al. 2020)
Cervical cancer Upregulation Oncogene Proliferation, apoptosis, invasion, and emt miR-200a Fus Zhu et al. 2018a)
Cervical cancer Upregulation Oncogene Proliferation and apoptosis miR-140-5p ORC1 Chen et al. 2019b)
Cervical cancer Upregulation Oncogene Proliferation, migration, invasion, and apoptosis miR-889-3p SIX1 Liu et al. 2020)
Thyroid cancer Upregulation Oncogene Proliferation, migration, and invasion miR-141 / Xu et al. 2018b)
Thyroid cancer Upregulation Oncogene Proliferation miR-34a MET-PI3K-AKT Liu et al. 2018)
Thyroid cancer Upregulation Oncogene Migration and invasion miR-101-3p CLDN1 Du et al. 2021)
Nasopharyngeal cancer Upregulation Oncogene Growth miR-34a-5p E2F3 Song et al. 2016)
Nasopharyngeal cancer Upregulation Oncogene Proliferation and radiosensitivity miR-29c / Han et al. 2017)
Nasopharyngeal cancer Upregulation Oncogene Proliferation, invasion, and apoptosis miR-491-5p / Cheng et al. 2018)
Nasopharyngeal cancer Upregulation Oncogene Proliferation, metastasis, and emt miR-148a-3p ADAM17 Shi et al. 2020)
Nasopharyngeal cancer Upregulation Oncogene Glycolysis, migration, and invasion miR-381-3p NEK5 Zhao et al. 2020)
Melanoma Upregulation Oncogene Proliferation and apoptosis miR-23a-3p GINS2 Hao et al. 2021)
Leukemia Upregulation Oncogene Drug resistance, viability, and apoptosis miR-29a MYC Wang et al. 2020a)