Fig. 3
From: Perspectives and potential approaches for targeting neuropilin 1 in SARS-CoV-2 infection
Potential approaches to targeting NRP1 for the treatment of SARS-CoV-2 infection in patients with or without comorbidities. Expressed in temporary restricted manner in the embryo, NRP1 is important for cardiovascular and pulmonary system development. NRP1 expression was not detected in healthy pancreas or in pancreatitis but was upregulated in pancreatic cancer. Most evidence point to tissue-damaging role of NRP1 in all types of cancer. NRP1 ligand VEGF165 plays critical role in asthma whereas NRP1 is protective in COPD pathobiology