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Fig. 2 | Molecular Medicine

Fig. 2

From: Targeting CK2 mediated signaling to impair/tackle SARS-CoV-2 infection: a computational biology approach

Fig. 2

Interference of IFN signaling by Orf6 and the role of CIGB-300. a Interferon, on binding to the receptor, induces STAT1 phosphorylation and the formation of a complex with STAT2 and IRF9. KPNA1 binds with the complex, and KPNB1 binds to KPNA1 and thereby chaperons the complex through the nuclear pore. b Orf6 retains KPNA1 and KPNA2 in the ER/Golgi membrane and the transport of the STAT complex to the nucleus is interrupted. c CIGB-300 blocks the interaction of Orf6 with KPNA2 and the transport of the STAT complex to the nucleus is restored

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Molecular Medicine

ISSN: 1528-3658