Fig. 8

Network of proteins with phosphosites activated in at least two SARS-CoV-2 studies and inhibited by CIGB-300. The phospho-acceptor sites inhibited by CIGB-300 are shown for each protein. Proteins involved in more significant pathways are grouped and colored: mRNA metabolism (pink circle), Cell Cycle (yellow circle) and ‘Selective Autophagy’ (blue circle). The five nodes with the highest degree (HNRNPA1, HSPB1, SRRM2, NPM1 and SRRM1) are labeled with (•)