Fig. 1

Omega-3 FAs alleviate inflammatory response and oxidative stress injury of intestinal epithelial cells induced by CLP. A Body weight of mice with different treatment within 3 days after sepsis induction. B Survival rate of mice with different treatment within 3 days after sepsis induction. C Bacterial content in peritoneal lavage fluid and blood of mice with different treatment. D The levels of ROS and MDA and the activity of SOD as detected by ROS, MDA and SOD detection kits. E The expression of TNF-α, IL-1β and IL-6 in serum of mice with different treatment as determined by ELISA. F Pathological changes of intestinal tissues of mice with different treatment as observed by HE staining. G The pathological changes of colonic mucosa as observed by TEM. H The miR-1-3p expression in intestinal tissues of mice determined by RT-qPCR; n = 8. The apoptosis of intestinal tissues as examined by TUNEL staining. *p < 0.05. Measurement data were expressed as mean ± standard deviation. One-way ANOVA with Tukey’s test was used for data analysis among multiple groups, and repeated measures ANOVA with Tukey's test for data analysis at different time points. Experiment was repeated independently three times