Fig. 1

Methodological approaches for the analysis of the multimodal neuroimaging data. In A, analyses of ³¹P-MRSI measurements are summarized; in B, the approach on calculations of CNRs (as derived from SWI). Panel A.1 illustrates the voxel size and CSI grid placement (green) for ³¹P-MRSI measurements in axial, coronal, and sagittal planes. In Panel A.II, the voxels of interest (VOIs) for subcortical brain regions are highlighted for each hemisphere (orange hatched). One exemplary ³¹P-MRSI spectrum (white line) and the respective model line fit (red line) is shown in Panel A.III. The metabolites of relevance for this study are labeled in yellow. For the sake of readability, other peaks are not marked, as they were not of interest to the hypothesis of this study. In Panel B.I, an exemplary SWI image of one study participant in the axial plane is shown. In Panel B.II, we highlighted the reference ROI placement (blue circles) in the lateral ventricles by a magnified snippet (blue framework). 31P-MRSI ³¹Phosphorus magnetic resonance spectroscopy imaging. ATP adenosine triphosphate, CSI chemical shift imaging, iP inorganic phosphate, PCr phosphocreatinine, ppm parts per million, ROI region of interest, SWI susceptibility-weighted imaging, VOI voxel of interest