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Table 1 Summary of multiple regression model results of (βATP + PCr)/iP vs. SWI CNR values

From: Relationship between brain iron deposition and mitochondrial dysfunction in idiopathic Parkinson’s disease

Analysis of variance

SS

DF

MS

F

p-value

 

Regression

48.79

4

12.20

F(4,57) = 41.39

P < .0001****

 

SWI: putamen (CNR)

15.46

1

15.46

F(1,57) = 52.46

P < .0001****

 

SWI: caudate (CNR)

2.00

1

2.00

F(1,57) = 6.78

P = .0117*

 

SWI: globus pallidus (CNR)

2.98

1

2.98

F(1,57) = 10.10

P = .0024**

 

SWI: thalamus (CNR)

0.79

1

0.79

F(1,57) = 2.68

P = .1074

 

Residual

16.80

57

0.29

   

Total

65.58

61

    

Parameter Estimates

Variable

Estimate

SE

95% CI

T

p-value

β0

Intercept

1.36

0.31

0.74; 1.98

4.39

P < .0001****

β1

SWI: putamen (CNR)

4.44

0.61

3.21; 5,67

7.24

P < .0001****

β2

SWI: caudate (CNR)

0.27

0.10

0.06; 0.48

2.60

P = .0117*

β3

SWI: globus pallidus (CNR)

0.19

0.06

0.07; 0,31

3.18

P = .0024**

β4

SWI: thalamus (CNR)

0.10

0.05

0.00; 0.18

1.64

P = .1074

Goodness of Fit

     

DF

57

     

Multiple R

0.86

     

R2

0.74

     

R2adj

0.73

     

SS

0.74

     

RMSE

0.11

     

Multicollinearity

Variable

VIF

R2 with other variables

   

β0

Intercept

     

β1

SWI: putamen (CNR)

1.59

0.37

   

β2

SWI: caudate (CNR)

1.18

0.15

   

β3

SWI: globus pallidus (CNR)

1.29

0.22

   

β4

SWI: thalamus (CNR)

1.21

0.17

   

Normality of Residuals

Statistics

p-value

Passed normality test (α = .05)?

   

Anderson and Darling (1952)

0.58

P = 0.13

Yes

   

D’Agostino et al. (1990)

2.23

P = 0.33

Yes

   

Shapiro and Wilk (1965)

0.97

P = 0.16

Yes

   

Massey (distance) (1951)

0.08

P > .10

Yes

   
  1. The table summarizes the multiple regression model of (βATP + PCr)/iP vs. SWI CNR values, including descriptive analyses. Apart from the overall significance test of the model, parameter estimates, goodness of fit, and necessary assumptions for multiple regression models were tested (absence of multicollinearity and normality of residuals). */**/***/***: significance levels (*: P ≤ 0.05, **: P ≤ 0.01, ***: P ≤ 0.001; ****: P ≤ 0.0001)
  2. CI confidence interval, CNR contrast-to-noise ratio, DF degrees of freedom, MS mean square, R2 coefficient of determination, R2adj adjusted coefficient of determination, RMSE root mean square error, SE standard error, SS sum of squares, SWI susceptibility-weighted imaging, T t-statistic, F F-Statistic, VIF variance inflation factor
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Molecular Medicine

ISSN: 1528-3658