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Fig. 5 | Molecular Medicine

Fig. 5

From: Abnormal lipid droplets accumulation induced cognitive deficits in obstructive sleep apnea syndrome mice via JNK/SREBP/ACC pathway but not through PDP1/PDC pathway

Fig. 5

LDs accumulation in glial cells. The microglia marker Iba-1 (red), astrocyte marker GFAP (red) and DAPI (blue) were stained with BODIPY (483/503) (green) to observe LDs accumulation in glia. The swollen cell body and increased synapses along with the mass of BODIPY (483/503) spots could be observed in glial cells after CIH exposure. With SMND-309 treatment, glial injuries were relieved. LDs accumulated (yellow, black arrow) could also be detected in astrocytes (A) and microglia (B). C Quantification of LDs accumulation in astrocytes. D Quantification of LDs accumulation in microglia. *p < 0.05 WT group vs. WT CIH group. **p < 0.05 WT CIH group vs. SMND-309 CIH group. All experiments were repeated three times. Data are shown as the mean ± SEM. Statistical analysis included two-way ANOVA. Original magnification: 400×

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Molecular Medicine

ISSN: 1528-3658