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Fig. 1 | Molecular Medicine

Fig. 1

From: Ketogenic diet ameliorates lipid dysregulation in type 2 diabetic mice by downregulating hepatic pescadillo 1

Fig. 1

Ketogenic diet decreased the hyperglycemia and ameliorated insulin resistance in diabetic mice. a Shown are the changes of body weights exerted by the different food feedings in normal and diabetic mice. b Displayed are the food intakes in different groups throughout 16 weeks of feeding. c Exhibited are the water intakes in different groups throughout 16 weeks. d Demonstrated are the total energy intakes calculated by calories in different groups throughout 16 weeks. e Unveiled are the feeding efficiencies in different groups (calculated as body weight gain (mg) per kcal food consumed). f Shown are the variations of fasting plasma glucose in different groups throughout 16 weeks. g Intraperitoneal glucose tolerance tests were performed in different groups by the end of food feeding. h Intraperitoneal insulin tolerance tests were carried out in different groups by the end of food feeding. Glucose (2 mg/g) or insulin (0.75 mU/g) was injected intraperitoneally after mice were fasted for 6–8 h. Blood glucose samples were collected at different indicated time points and measured. Areas under the curve were calculated for the quantitative analysis. i Demonstrated are the levels of plasma β-hydroxybutyric acid (β-HB) in different groups. j Insulin levels were detected in different groups by the end of food feeding. k HOMA-IR in different groups was calculated by the formula. Data were shown as mean ± SEM for each experiment performed independently 3 times (n = 10–12 per group). SD (Standard diet), KD (Ketogenic diet). *P < 0.05 C57BL/6J-KD vs C57BL/6J-SD, #P < 0.05 KKAy-KD vs KKAy-SD (ANOVA, Student–Newman–Keuls q test)

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