Fig. 2
KD suppressed the PES1 expression and decreased plasma and hepatic TG levels in normal and diabetic mice. a, b The protein levels of hepatic CHOP, PES1, p300, SREBP1c, SREBP2, FASN and SCD1 were detected by Immunoblotting. c The oil red O and H&E staining of liver tissues were performed for different groups, original magnification, ×10. Scale bar, 50 μm. d Plasma TG and TC were assayed for different groups by the end of food feeding. e Hepatic TG and TC levels were detected for different groups. f Plasma AST and ALT levels were measured by Reagent kit. Values are means ± SEM for each experiment performed independently 3 times. SD (Standard diet), KD (Ketogenic diet). *P < 0.05, **P < 0.01, ***P < 0.001 compared with control for C57BL/6J, #P < 0.05, ##P < 0.01, ###P < 0.001 compared with control for KKAy (ANOVA, Student–Newman–Keuls q test)