Fig. 5

Effects of liver-specific Pes1 knockout on lipid metabolism in vivo. a Displayed is the scheme of Pes1 gene knockout strategy. b Shown are the effects of Pes1 knockout on the murine body weights. c, d Pes1 knockout in mice eliminated the protein levels of PES1, and inhibited p300, SREBP1c, FASN and SCD1 proteins. e–g Shown are the effects of Pes1 knockout on the weights of livers and fat. h, i Demonstrated are the effects of Pes1 knockout on the TG and TC levels in murine plasma and livers. j Plasma AST and ALT levels were measured by Reagent kit. Data were shown as mean ± SEM for each experiment performed independently 3 times. *P < 0.05, **P < 0.01, ***P < 0.001 compared with control (Student’s t test)