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Fig. 8 | Molecular Medicine

Fig. 8

From: Ketogenic diet ameliorates lipid dysregulation in type 2 diabetic mice by downregulating hepatic pescadillo 1

Fig. 8

β-HB lowered PES1 binding to the Caspase1 promoter and Caspase1 knockdown in hepatocytes reduced the medium and cellular TG. a, b Caspase1 knockdown in liver cells suppressed the inflammation proteins. c Shown are the effects of Caspase1 knockdown on the relative mRNA levels of cellular IL-1β and IL-18. d, e Caspase1 knockdown in liver cells reduced the medium and cellular TG. f β-HB decreased PES1 binding to the Caspase1 gene promoter. g Schematic diagram of the entire study. Data were shown as mean ± SEM for each experiment performed independently 3 times. *P < 0.05, **P < 0.01, ***P < 0.001 compared with control (Student’s t test)

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Molecular Medicine

ISSN: 1528-3658