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Table 3 Effect of administration of QUE and/or MTX on paw volume

From: Quercetin mitigates rheumatoid arthritis by inhibiting adenosine deaminase in rats

Groups Day (0) Day (7) Day (14) Day (21) Day (28)
Normal control 0.11 ± 0.009 0.133 ± 0.0045 0.137 ± 0.004 0.1331 ± 0.005 0.129 ± 0.003
Rheumatoid arthritis control 0.115 ± 0.004 1.032 ± 0.0078**** 0.809 ± 0.013**** 0.863 ± 0.024**** 0.809 ± 0.013****
Methotrexate control 0.116 ± 0.006 0.13 ± 0.0058 0.102 ± 0.005 0.073 ± 0.002 0.070 ± 0.008
Quercetin control 0.122 ± 0.002 0.135 ± 0.0042 0.152 ± 0.002 0.132 ± 0.001 0.131 ± 0.001
Methotrexate treatment 0.127 ± 0.002 1.031 ± 0.0137**** 0.898 ± 0.052**** 0.408 ± 0.030+++,**** 0.291 ± 0.029++++,**
Quercetin treatment 0.122 ± 0.002 1.026 ± 0.0096**** 0.72 ± 0.032**** 0.51 ± 0.048++,**** 0.44 ± 0.030+++,***
Combination treatment 0.128 ± 0.002 1.032 ± 0.0079**** 0.869 ± 0.016**** 0.369 ± 0.016++++,*** 0.233 ± 0.030++++,**
  1. p < 0.05 is considered significant, where +: significantly different from the RA control group and *: significantly different from the normal control groups. Results are expressed as mean ± SE, (n = 8)