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Fig. 6 | Molecular Medicine

Fig. 6

From: Pro-inflammatory mediators released by activated monocytes promote aortic valve fibrocalcific activity

Fig. 6

Schematic diagram depicting the mechanism underlying AVIC fibrocalcification induced by medium conditioned by activated monocytes. Pro-inflammatory mediators produced by monocytes activated by TLR-2 agonist induce AVIC fibrocalcification involving up-regulation of fibrogenic and osteogenic mediators. RANTES contributes to the fibrogenic response induced by Pam3 CM through activation of JNK, and TNF-α mediates the pro-fibrogenic and pro-osteogenic effects of Pam3 CM through activation of both JNK and NF-κB

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Molecular Medicine

ISSN: 1528-3658