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Fig. 4 | Molecular Medicine

Fig. 4

From: Long noncoding RNA XIST regulates brown preadipocytes differentiation and combats high-fat diet induced obesity by targeting C/EBPα

Fig. 4

XIST overexpression attenuates HFD-induced obesity in vivo. A Representative photograph of male mouse whole body images between groups. B Body weight of male mice between groups. CD, chow diet. HFD, high fat diet. *CD + pCMV-CON (n = 6) vs CD + pCMV-XIST (n = 6), p < 0.05; # HFD + pCMV-CON (n = 6) vs HFD + pCMV-XIST (n = 6), p < 0.05; $ CD + pCMV-CON vs HFD + pCMV-CON, p < 0.05; and CD + pCMV-XIST vs HFD + pCMV-XIST, p < 0.05; % CD + pCMV-CON vs HFD + pCMV-XIST, p < 0.05. G–H Insulin tolerance test and glucose tolerance test of male mice between groups. C–F Serum triglyceride, cholesterol, LDL-C and HDL-C levels in male mice between groups. *, p < 0.05. Data are represented as mean ± SEM

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Molecular Medicine

ISSN: 1528-3658