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Fig. 3 | Molecular Medicine

Fig. 3

From: Inhibition of β-catenin signaling attenuates arteriovenous fistula thickening in mice by suppressing myofibroblasts

Fig. 3

Expression of the endothelial marker Tie2 in myofibroblasts of AVF. Sham operated IVC specimens were obtained at 6 weeks post-operation. AVF specimens were obtained at 2, 4, and 6 weeks post-operation. A–D IF images double stained for Tie2 and αSMA (arrowhead, double-positive cells in tunica media; scale bar = 10 μm). E Quantification of Tie2/αSMA double-positive cells in tunica media. Data are presented as median, 1st and 3rd quartiles, maximal and minimal values in the box plots (n = 6 per group). P values were determined by the Wilcoxon signed-rank test with Bonferroni correction. Insignificant P values are not shown. Images were obtained by confocal microscopy. AVF arteriovenous fistula, IVC inferior vena cava, IF immunofluorescence, αSMA smooth muscle alpha-actin, Lu lumen

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Molecular Medicine

ISSN: 1528-3658