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Table 1 L–R differential methylation of ion channels in in-vivo and in-silico studies

From: When left does not seem right: epigenetic and bioelectric differences between left- and right-sided breast cancer

More methylated right More methylated left
Gene symbol* Channel function Gene symbol* Channel function
Ion channels from in-vivo assays
 CHRNE Depolarization ASIC2 Depolarization
 HTR1A Depolarization CACNA1A Depolarization
 PIEZO2 Depolarization CACNA2D2 Depolarization
 RYR3 Depolarization CATSPERD Depolarization
 TRPC7 Depolarization PKD1L1 Depolarization
 TRPM8 Depolarization TRPM4 Depolarization
 ANO2 Hyperpolarization ANO3 Hyperpolarization
 ATP1A3 Hyperpolarization ANO5 Hyperpolarization
 ATP6V1C2 Hyperpolarization CLCN1 Hyperpolarization
 ATP6V1H Hyperpolarization CLIC5 Hyperpolarization
 GABBR1 Hyperpolarization GABBR2 Hyperpolarization
 KCNA7 Hyperpolarization GABRA5 Hyperpolarization
 KCNB1 Hyperpolarization GABRD Hyperpolarization
   GABRG1 Hyperpolarization
   KCNH2 Hyperpolarization
   KCNIP3 Hyperpolarization
   KCNJ18 Hyperpolarization
   KCNK9 Hyperpolarization
   KCNN1 Hyperpolarization
   VDAC2 Hyperpolarization
Ion channels from in-silico assays
 CACNA1D Depolarization CACNA2D2 Depolarization
 CACNA1H Depolarization CACNA2D4 Depolarization
 CACNA1I Depolarization CHRNA1 Depolarization
 CACNB2 Depolarization CNGA1 Depolarization
 CACNG4 Depolarization HCN1 Depolarization
 CACNG6 Depolarization P2RX4 Depolarization
 CHRNA6 Depolarization PKD2 Depolarization
 CHRNB1 Depolarization RYR1 Depolarization
 CHRNB2 Depolarization SCN11A Depolarization
 CNGA3 Depolarization SCNN1A Depolarization
 GRIA1 Depolarization TRPM3 Depolarization
 HVCN1 Depolarization CFTR Hyperpolarization
 LRRC8D Depolarization CLCN1 Hyperpolarization
 LRRC8E Depolarization CLCNKB Hyperpolarization
 MCOLN2 Depolarization KCNA1 Hyperpolarization
 MCOLN3 Depolarization KCNA5 Hyperpolarization
 PKD2L2 Depolarization KCNC3 Hyperpolarization
 SCN3B Depolarization KCNH7 Hyperpolarization
 SCN9A Depolarization KCNH8 Hyperpolarization
 SCNN1G Depolarization KCNJ9 Hyperpolarization
 TRPA1 Depolarization KCNMA1 Hyperpolarization
 TRPC2 Depolarization KCNS2 Hyperpolarization
 TRPC3 Depolarization   
 TRPM2 Depolarization   
 TRPM6 Depolarization   
 TRPV3 Depolarization   
 TRPV4 Depolarization   
 TRPV6 Depolarization   
 CLIC3 Hyperpolarization   
 GABRA2 Hyperpolarization   
 GABRG1 Hyperpolarization   
 GABRP Hyperpolarization   
 GABRR1 Hyperpolarization   
 GLRA3 Hyperpolarization   
 GLRB Hyperpolarization   
 KCNA2 Hyperpolarization   
 KCNA6 Hyperpolarization   
 KCNA7 Hyperpolarization   
 KCNG1 Hyperpolarization   
 KCNH1 Hyperpolarization   
 KCNH4 Hyperpolarization   
 KCNH6 Hyperpolarization   
 KCNJ15 Hyperpolarization   
 KCNJ2 Hyperpolarization   
 KCNJ5 Hyperpolarization   
 KCNJ6 Hyperpolarization   
 KCNK3 Hyperpolarization   
 KCNK4 Hyperpolarization   
 KCNK5 Hyperpolarization   
 KCNN4 Hyperpolarization   
 KCNQ3 Hyperpolarization   
 KCNQ4 Hyperpolarization   
 KCNS1 Hyperpolarization   
 KCNS3 Hyperpolarization   
 KCNT2 Hyperpolarization   
  1. *HUGO Gene Nomenclature Committee (HGNC)